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KMID : 1197720190120030172
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대한파킨슨병 및 이상운동질환 학회지
2019 Volume.12 No. 3 p.172 ~ p.176
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The Impact of Impulsivity on Quality of Life in Early Drug-Naive Parkinson’s Disease Patients
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Ryu Dong-Woo
Kim Joong-Seok
Yoo Sang-Won
Oh Yoon-Sang
Lee Kwang-Soo
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Abstract
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Objective: Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naive PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naive PD patients.
Methods: Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Results: Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naive PD patients.
Conclusion: The results of the present study showed that impulsivity negatively influences QOL in early drug-naive PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.
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KEYWORD
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Impulse control disorder, Impulsivity, Parkinson’s disease, Quality of life
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